Van de Ven Brace Halts Everton's Run at New Stadium
The Dutch defender became the initial defender to score twice in a English top-flight match for Spurs since the Belgian defender in March 2013.
At a glance
Micky Van de Ven heads home two times in first half
The home side's Jake O'Brien has equalizer disallowed after VAR review
Pape Matar Sarr scores final goal in dying moments
The defeat is Everton's initial at their new ground
The Tottenham defender scored on two occasions as Spurs extended their unbeaten run in away games in the top division and delivered the Toffees their first defeat at their new home.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman pounced twice from corners in the first half to place their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a final goal to put the game to bed.
The Everton defender believed he had equalized the scores a short while after the defender's opener, directing a bullet header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a number of chances, while Vicario made a series of excellent stops to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee intervened, advising the match official to check the score on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates the manager's team into third place in the Premier League, a handful of points off north London rivals and table-toppers the Gunners.
The Merseyside club stay in 14th position and sit six points ahead of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at both ends of the field
After a uninspiring midweek performance in the European competition against the French side, where they managed a mere attempts on target, the manager opted for the French striker in attack instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being substituted for the substitute after 60 minutes on the pitch, but it emerged he wasn't needed in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Tottenham's first goal came from a well-worked corner routine, with Rodrigo Bentancur directing the ball back across the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - filling in as captain in the Argentine's absence - added his second in added time as he outjumped the England keeper to head home.
The Dutchman was just as impressive in defensive duties, partnering well with Kevin Danso as the pair handled excellently with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees missing striker's instinct
The club's new home had been a fortress, but it appears the freshness may have worn off somewhat and fans flocked to the gates after Sarr's final goal for Spurs.
The end in Everton's unbeaten home run will not be a massive concern for David Moyes, but their attacking woes will be.
Beto and Thierno Barry - the Everton's pair of recognised strikers - had netted just one league goal between them before the weekend's match.
And they were failed to contribute to that miserable tally on a wet and gloomy night on in Liverpool.
The striker's performance was summed up when he opted to overhead kick a clear chance from near the goal, despite having room and opportunity to reposition for a simpler attempt that would have challenged the keeper.
Barry, too, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly whipped threatening crosses into the Tottenham box.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Tottenham: Spurs go to St James' Park on late October for their next round Carabao Cup tie against Newcastle.